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Complex Cases

Work through challenging cases with multi-system involvement and unclear diagnoses.

A 42-year-old female with a past medical history of HTN, Diabetes and Afib initially presented to primary care with a 1-month history of bilateral upper extremity and lower extremity urticaria. Lesions were characterized as pruritic hives, with each lesion lasting greater than 24 hours and with residual hyperpigmentation following resolution. These symptoms were associated with a 10-year history of intermittent low-grade fevers and night sweats which had previously been worked up without identification of a clear etiology. She has elevated CRP and M Protein Spike

What are the risks and benefits of starting glp 1 inhibitors in a diabetic patient with gastroparesis and systolic heart failure (EF 40%). Provide data on the different glp 1 inhibitors and SGL2 inhibitors.