OpenEvidence is the most widely used medical AI among verified U.S. physicians, with over 100 million AI-powered clinical consultations completed to date. OpenEvidence gives comprehensive, evidence-based answers to clinical questions — grounded in peer-reviewed literature from NEJM, JAMA, NCCN, Cochrane, and more.

Unlike general-purpose AI, OpenEvidence is built specifically for clinical decision-making. Every answer cites its sources, grounding answers in the guidelines and medical literature and supporting exploration of the evidence. Clinicians use it for quick consults, differential diagnosis, treatment options, drug information, guideline summaries, prior authorizations, patient education, and much more.

Use the sections to the left to explore what OpenEvidence can do and how to get the most out of it.