User Guide Contents
When exploring treatment options or searching for trials, OpenEvidence automatically surfaces active and recruiting clinical trials and evaluates each one against your patient's clinical context — matching disease, treatment history, and eligibility criteria to help you identify the most relevant options.
Finding relevant clinical trials is as simple as asking for them — whether you're explicitly searching or exploring treatment options for your patient.
60 year old male with HTN, T2DM otherwise healthy with diagnosis of metastatic CRPC. Initially presented 2018 with high risk localized disease (GS4+5=9, PSA 20, cT2 disease), and underwent EBRT and ADT x 2 years. Subsequent PSA nadir undetectable. Subsequently with polymetastatic recurrence 2025 with PSMA PET avid disease widespread in bone and pelvic/retroperitoneal lymph nodes and PSA 15. Initiated on Lupron+zytiga, again progressed after 1 year. His most recent PSMA PET shows worsening bone disease and now mediastinal lymphadenopathy and new PSMA PET avid lung lesions, biopsy confirmed prostate adenocarcinoma. Somatic NGS shows p53 mutation. Negative for BRCA mutations. Germline was negative.
Every trial is evaluated against your patient's clinical context and categorized by relevance:
We also surface basket trials — tumor-agnostic studies that enroll patients across multiple cancer types when they share common molecular features or biomarkers.
Each trial card displays phase, enrollment status, sponsor, and key eligibility details at a glance.
To surface trials near your patient, include location in your query or use the location filter. Distance to each trial site is displayed directly on the card, helping you quickly identify accessible options for your patient.
You can navigate directly to any trial to see full details, eligibility criteria, and contact information.